Patient characteristics and TFS/OS analysis.

aMutational status is based on a 98% cut-off value.bThe cut-off determined using ROC curve analysis maximising the concordance with the IgVH status.cAmong patients with unfavorable cytogenetic abnormalities (n = 51), we found 9 patients with a del(17p), 13 with a del(11q), 10 with del(6q), and 18 with a trisomy-12. Furthermore, 1patient presents a complex karyotype associated with poor prognosis. Among patients with favorable cytogenetic abnormalities (n = 64), we found 31 patients with del(13q) and 3 patients with other(s) abnormalities. 30 patients had a normal karyotype.