Expressed mutated genes in Sezary syndrome and their potential prognostic value in patients treated with Extracorporeal Photopheresis

Whole Exome Sequencing (WES) analysis of genomic DNA samples obtained longitudinally from CD4+ T-lymphocytes derived from Sezary patients, matched Granulocytes and CD4- T-lymphocytes cells to identify single nucleotide variants (SNVs). The resulting variant calls were integrated with RNA-seq findings for validation purposes.