Spectrum of spontaneous rpoB-mutations obtained by method 1 (multiple parallel 1-ml cultures).

For strains H15, H26, H48 and H71 no mutants were obtained. Results for MTB72 (first row) and strains H103, 2001–2184 and 2001–2185 are obtained in the first experiment, where we assessed the influence of pre-existing INH resistance on the spectrum of mutations. Results for MTB72 (second row) and 9900098, 2001-1669 and 2001-1670 were obtained in the second experiment, where we determined the role of the LAM genotype on the spectrum of rpoB-mutations. Results for MTB72 (third row) and 9500592, 2002-1640, 2002-1585 and 17583 were obtained in the third experiment, where we determined the role of the Beijing genotype on the spectrum of rpoB-mutations. ins: insertion, dup: duplication, Δ: deletion.