Transcriptomic Analysis in Renal T Lymphocytes Exposes Sodium-Independent Dietary Differences in Dahl Salt-Sensitive Rats

Conclusions. These functional and transcriptomic T-cell differences between SS/MCW and SS/CRL show that sodium-independent dietary effects may influence the immune response and infiltration of immune cells into the kidney, ultimately impacting susceptibility to salt-induced hypertension and renal damage.结论。SS/MCW与SS/CRL品系间存在的功能性与转录组学水平T细胞差异表明，非钠依赖性膳食因素可影响机体免疫应答以及免疫细胞向肾脏的浸润，最终影响机体对盐诱导性高血压与肾损伤的易感性。