Berkeley Drosophila Genome Project insitu

In early 2010 we updated the site to facilitate more rapid transfer of our data to the public database and focus our efforts on the core mission of providing expression pattern images to the research community. The original database https://www.fruitfly.org/index.html reproduced functions available on FlyBase, complicating our updates by the requirement to re-synchronize with FlyBase updates. Our expression reports on the new site still link to FlyBase gene reports, but we no longer reproduce FlyBase functions and therefore can update expression data on an ongoing basis instead of more infrequent major releases. All the functions relating to the expression patterns remain and we soon will add an option to search expression patterns by image similarity, in addition to annotation term searches. In a transitional phase we will leave both the old and the new sites up, but the newer data (post Release 2) will appear only on the new website. We welcome any feedback or requests for additional features. - The goals of the Drosophila Genome Center are to finish the sequence of the euchromatic genome of Drosophila melanogaster to high quality and to generate and maintain biological annotations of this sequence. In addition to genomic sequencing, the BDGP is 1) producing gene disruptions using P element-mediated mutagenesis on a scale unprecedented in metazoans; 2) characterizing the sequence and expression of cDNAs; and 3) developing informatics tools that support the experimental process, identify features of DNA sequence, and allow us to present up-to-date information about the annotated sequence to the research community.

自2010年初起，我方对网站进行了升级，旨在加速数据向公共数据库的转移，并集中精力致力于核心使命——向科研界提供表达模式图像。原始数据库（https://www.fruitfly.org/index.html）复现了FlyBase上的功能，由于需要与FlyBase更新同步，使得我方的更新工作变得复杂。在新网站上，我们的表达报告依然链接至FlyBase的基因报告，但不再复现FlyBase的功能，因此可以持续更新表达数据，而无需像以往那样进行较为稀少的重大发布。所有关于表达模式的功能均得以保留，我们很快将新增通过图像相似性搜索表达模式的功能，除此之外，还将提供通过注释术语进行搜索的选项。在过渡阶段，我们将同时保留旧网站和新网站，但Release 2之后的新数据将仅在新网站上呈现。我们热切欢迎任何反馈或对新增功能的请求。Drosophila基因组中心的目标是完成Drosophila melanogaster核染色质基因组的测序工作，并达到高质量标准，同时生成并维护该序列的生物注释。除了基因组测序外，BDGP还进行以下工作：1）利用P元素介导的诱变技术在多细胞生物中前所未有地生产基因敲除；2）表征cDNA的序列和表达；3）开发支持实验过程、识别DNA序列特征并允许我们向科研界提供最新注释序列信息的计算工具。