CCR1

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

该基因编码β型趋化因子受体家族成员，预测为类似G蛋白偶联受体的七跨膜蛋白。该受体的配体包括巨噬细胞炎症蛋白1α（MIP-1α）、激活后正常T细胞表达和分泌蛋白（RANTES）、单核细胞趋化蛋白3（MCP-3）以及髓系祖细胞抑制因子-1（MPIF-1）。趋化因子及其受体介导的信号转导对于效应免疫细胞向炎症部位的募集至关重要。对小鼠同源基因的敲除研究提示了该基因在宿主抵御炎症反应以及病毒和寄生虫易感性方面的作用。该基因及其他趋化因子受体基因，如CCR2、CCRL2、CCR3、CCR5和CCXCR1，均发现位于3p染色体上的基因簇中。[由RefSeq提供，2008年7月]