Single cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease

"Single cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease"Arshad H. Khan1, Lydia K. Lee2, Desmond J. Smith1,31 Department of Molecular and Medical PharmacologyDavid Geffen School of Medicine, UCLALos Angeles, CA 90095-17352 Department of Obstetrics and GynecologyDavid Geffen School of Medicine, UCLALos Angeles, CA 90095-69283 To whom correspondence should be addressed:Department of Molecular and Medical PharmacologyDavid Geffen School of Medicine, UCLABox 951735, 23-151A CHSLos Angeles, CA 90095-1735Email: [e-mail]"Words" folder contains pdfs of the Manuscript and Supplementary Data."Supplementary_Tables" folder contains results from single cell RNA-seq (scRNA-seq) analysis."Behavior" folder contains data from pole and dot removal tests."Single_cell_RNA_data" folder contains scRNA-seq data from substantia nigra pars compacta (SNpc) of mice treated with combined dosing of the pesticides maneb and paraquat (MNPQ) or saline. Raw and filtered output from 10X Genomics Cell Ranger pipeline provided.

对由杀虫剂诱导的帕金森病小鼠模型 substantia nigra pars compacta 区（黑质致密部）中基因表达的单细胞分析

作者：Arshad H. Khan1, Lydia K. Lee2, Desmond J. Smith1,3
1分子与医学药理学系，David Geffen医学院，UCLA，洛杉矶，加利福尼亚州 90095-1732
2妇产科，David Geffen医学院，UCLA，洛杉矶，加利福尼亚州 90095-6928
3通讯地址：分子与医学药理学系，David Geffen医学院，UCLA，信箱951735，23-151A CHS，洛杉矶，加利福尼亚州 90095-1735
电子邮箱：[e-mail]

'Words' 文件夹包含手稿及补充数据的 PDF 文件。
'Supplementary_Tables' 文件夹包含单细胞 RNA 测序（scRNA-seq）分析的结果。
'Behavior' 文件夹包含杆和点去除测试的数据。
'Single_cell_RNA_data' 文件夹包含经杀虫剂 maneb 和 paraquat（MNPQ）或盐水联合给药处理的小鼠 substantia nigra pars compacta（SNpc）的单细胞 RNA 测序（scRNA-seq）数据。提供 10X Genomics Cell Ranger 工具流程的原始和过滤输出。