Identification of genetic markers associated with clinical response of ketose treatment in Holstein cows

<strong>Additional File</strong> <strong>1</strong>- <strong>Table S1.</strong> Mean and standard deviations of blood BHB concentration (mmol/L) for groups of cows classified as Chronic, Cured, Recurrent, and Severe considering their responses to the administration of propylene glycol and 50% dextrose to control hyperketonemia between 1st and 4nd week of lactation. <strong>Additional File</strong> <strong>2</strong>- <strong>Spreadsheet S1.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Cured vs Resistant contrast, <strong>Spreadsheet S2.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Severe vs Resistant contrast. <strong>Spreadsheet S3.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Chronic vs Resistant contrast,<strong> Spreadsheet S4.</strong> List of genes, SNP and their functional consequences associated with ketosis identified through Recurrent vs Resistant contrast.<strong> </strong> <strong>Additional File</strong> <strong>3</strong>-<strong> Spreadsheet S1. </strong>Pathways associated with genes identified to Cured vs Resitant contrast, <strong>Spreadsheet S2. </strong>Pathways associated with genes identified to Severe vs Resitant contrast,<strong> Spreadsheet S3. </strong>Pathways associated with genes identified to Chronic vs Resitant contrast,<strong> Spreadsheet S4. </strong>Pathways associated with genes identified to Recurrent vs Resitant contrast,<strong> Spreadsheet S6.</strong> Pathways associated with genes set identified among 4 analyzed contrasts (Cured, Severe, Chronic and Recurrent compared with Resistant, respectively), <strong>Spreadsheet S7.</strong> Protein Interaction network associated with genes set identified among 4 analyzed contrasts (Cured, Severe, Chronic and Recurrent compared with Resistant, respectively). <strong>Additional File</strong> <strong>4</strong>- <strong>Spreadsheet S1.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Cured vs Resistant contrast analysis, <strong>Spreadsheet S2.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Severe vs Resistant contrast, <strong>Spreadsheet S3.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Chronic vs Resistant contrast, <strong>Spreadsheet S4.</strong> Go terms and QTL associated with genes and SNPs related to ketosis identified through Recurrent vs Resistant contrast.