SARS-CoV-2疫苗免疫数据集

SARS-CoV-2的突破性感染是一项严峻的挑战，因为在完全接种疫苗的个体中记录到不断增长的感染病例。抗体反应差的受者极易再次感染，而抗体反应强的受者则可实现完全免疫。到目前为止，仍然缺乏与疫苗引发的抗体反应水平相关的生物标志物。本数据集提供了一个接受过灭活 SARS-CoV-2 疫苗的健康人群所对应的抗体反应，并在连续收集的样本中分析了 B 细胞受体库。接种疫苗后，所有接种过疫苗的个体都检测出共同的常见抗体克隆和数据库内的中和抗体。值得注意的是，通过疫苗接种前个体抗体V基因的使用偏好性以及IgG与IgM mRNA含量的比例，可以将低水平疫苗应答者与强水平疫苗应答者区分开来。这些发现揭示了疫苗诱导后不同水平的抗体反应相关的分子特征，这些特征可以进一步发展为设计新型疫苗接种策略的生物标志物。

SARS-CoV-2 breakthrough infections represent a substantial challenge, as a growing number of infection cases have been documented in fully vaccinated individuals. Individuals with poor antibody responses are highly susceptible to reinfection, while those with robust antibody responses can achieve full immunity. To date, biomarkers correlated with the level of vaccine-elicited antibody responses remain lacking. This dataset provides antibody response data from a healthy cohort that received inactivated SARS-CoV-2 vaccines, and includes analyses of B cell receptor repertoires from serially collected samples. Following vaccination, all vaccinated individuals were found to harbor common shared antibody clones and neutralizing antibodies present in the associated database. Notably, the pre-vaccination preferential usage of antibody V genes and the ratio of IgG to IgM mRNA levels can effectively distinguish low vaccine responders from strong vaccine responders. These findings uncover the molecular characteristics associated with varying levels of post-vaccination antibody responses, which can be further developed into biomarkers for designing novel vaccination strategies.

搜集汇总

背景与挑战

背景概述

该数据集聚焦于SARS-CoV-2疫苗免疫研究，提供了健康人群接种灭活疫苗后的抗体反应数据和B细胞受体库分析，旨在揭示疫苗诱导抗体反应的分子特征，并探索区分不同应答水平的潜在生物标志物，以支持新型疫苗接种策略设计。数据集规模较小，包含2个文件，总数据量28.88KB。