Microarray expression data of E7386-treated HSC3 cells

E7386 inhibits interaction between B-catenin and CREB-binding protein (CBP), which drives oncogenic gene expression and aggressive cancer phenotypes in oral squamous cell carcinomas (OSCC). We use microarrays to profile the effects of E7386 treatment on gene expression of HSC3 human OSCC cells. Three separate wells (triplicate) in 6-well plates were seeded with HSC3 cells (at 5 × 104/well). After 12–24 hours (ie, ∼ 50% confluency), the cells were treated with either 0.1% dimethyl sulfoxide (DMSO) or 0.1 μM E7386 in DMSO. After 48–64 h, the cells were trypsinized and harvested for RNA purification using the miRNeasy Micro Kit (QIAGEN no. 217084).