Gene expression microarray analysis on the dentate gyrus of Schnurri-2 knockout and wild-type control mice

Schnurri-2 (Shn-2), an NF-kappa B site-binding protein, tightly binds to the enhancers of major histocompatibility complex (MHC) class I genes and inflammatory cytokines, which have been shown to harbor common variant single nucleotide polymorphisms associated with schizophrenia. Shn-2 knockout mice show behavioral abnormalities that strongly resemble those of schizophrenics. We performed gene expression microarray analysis of dentate gyri from Shn-2 knockout and wild-type control mice. Dentate gyrus RNA isolated from six Shn-2 knockout and six control wild-type mice were compared.施努利蛋白2（Schnurri-2，Shn-2）作为一种核因子κB（NF-κB）结合位点蛋白，可紧密结合主要组织相容性复合体（MHC）I类基因与炎性细胞因子的增强子区域；现有研究证实，这些区域携带有与精神分裂症相关的常见变异型单核苷酸多态性（single nucleotide polymorphisms）。施努利蛋白2基因敲除小鼠所表现出的行为异常，与精神分裂症患者的行为特征高度相似。本研究对施努利蛋白2基因敲除小鼠及野生型对照小鼠的齿状回（dentate gyrus）开展了基因表达芯片分析，并对比了6只基因敲除小鼠与6只野生型对照小鼠的齿状回RNA样本。