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Effect of blocking IFNgamma on the transcriptomics of phagocytic or non-phagocytic microglia from miR-155 cKO mice.

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE220304
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Investigate whether miR-155 deletion activates microglia through interferon-dependent mechanism. WT and miR-155 cKO mice were treated with IFNgamma blocker or IgG control i.p. and intracerebral injection. Apoptotic neurons were stereotaxically injected into the cortex and hippocampus. After 16 hours, phagocytic/non-phagocytic microglia were sorted for RNAseq.
创建时间:
2023-07-11
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