Metabolomics NMR2025.xlsx

Biological significanceGrowing evidence suggests that proper immune function depends on a functional metabolism and in turn metabolic reprogramming influences the immune response to environmental triggers. The underlying metabolism in sarcoidosis, a chronic granulomatous disease, is unknown. Metabolomics could provide new insights into the pathophysiology of sarcoidosis by identifying distinct serum metabolic perturbations. Therefore, the objective of this study is to analyze the serum metabolomic profile of sarcoidosis patients and investigate if aberrant metabolites, at least in part, contribute to inflammation in sarcoidosis. Using an NMR-based metabolomic platform, we determined that three major pathways are affected in this disease: Serum metabolomic analysis using ¹H NMR.