five

Cyclic β-Peptoids

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Cyclic_Peptoids/2953564
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资源简介:
The first synthesis of functionalized β-peptoid macrocycles is reported. X-ray crystallographic structure of tetramer 9 reveals a C2-symmetrical derivative with unexpected all-cis-amide bonds and spatial disposition of the appendages toward the two opposite faces of the ring. Quantum calculations suggest that 9 is locked in this layout. These macrocycles constitute novel promising templates for multimeric ligation of biologically active ligands. The concept was exemplified by chemical decoration of tetramer 9 via “click” reactions.
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2016-06-03
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