The number of carriers for each mutation stratified by BMI category and their impact on obesity.

*Because there are mutations for which there were no normal-weight carriers, we added a constant (“+1”) to the number of carriers with obesity (numerator) and to the number of carriers of normal weight (denominator) to allow deriving “proxy” ORs. **Functional evidence refers to existing literature that demonstrated that the mutation leads to lower expression, impaired signaling or loss of function. "Ambiguous" refers to mutations that had conflicting reports of either supporting or refuting downstream effects or for which the loss of function effects of the mutation were not clear. BMI, body mass index; OR, odds ratio. (XLSX)