Transient protein structure guides surface diffusion pathways for electron transport in membrane supercomplexes

Presented are data supporting the work of investigating the functional role of yeast QCR6, an intrinsically disordered subunit of the respiratory complex III, in the yeast mitochondrial respiratory electron transport chain under the setting respiratory supercomplexes. These data reveal a cooperativity between QCR6 and the mitochondrial membrane condition to regulate and even improve the energy conversion efficiency of the supercomplex. These data also reveal a refined model on the enzymatic diffusion that is compatible of recent experimental discoveries concerning electron transport across subunits of supercomplex.