File S1 - A Novel Model of Chronic Wounds: Importance of Redox Imbalance and Biofilm-Forming Bacteria for Establishment of Chronicity

Figure S1, Schematic illustration of oxidative and nitrosative stress cycle. Figure S2, Lactate levels, pH, and nitrosative stress are exacerbated in old LIGHT−/− mice. Figure S3, Detrimental effects of exacerbated stress on protein modification, lipid peroxidation, and DNA damage in old mice. Figure S4, Histology of normal wound healing. Figure S5, Manipulation of LIGHT−/− wounds with bacteria or individual antioxidant inhibitors does not lead to chronic wound development. Figure S6, Identification and characterization of the bioflora that colonized the old LIGHT/- chronic wounds. (PDF)