Genome Wide Association Study in Familial Crohn's Disease

The National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium (NIDDK - IBDGC) conducted a genome wide association study (GWAS) using the Human Omni2.5-Quad beadchip from Illumina to identify disease variants associated with familial Crohn's disease. This study includes a subset of individuals from an original cohort of affected subjects and affected/unaffected relatives from a previous linkage scan which showed increased linkage evidence at three novel risk loci. A total of 708 samples were selected based on various criteria for inclusion from the 6 Genetic Research Centers (GRC) in North America that participate in the IBDGC. This project was supported by an ancillary R01 grant from the NIDDK with resources made available through the IBDGC.]]>
Inclusion Criteria: Proper consent and IRB approval for release of data to dbGaP Non-Hispanic Caucasian Confirm diagnosis of IBD and relatives/family members ]]>
These samples were part of a SNP Linkage Scan conducted at the Center of Inherited Disease Research (CIDR) in 2005-2006.]]>