Palladium-Catalyzed Carbohalogenation: Bromide to Iodide Exchange and Domino Processes

Aryl bromides have been used to prepare a variety of nitrogen- and oxygen-containing heterocycles featuring new carbon–carbon and carbon–iodine bonds. This palladium-catalyzed carbohalogenation requires potassium iodide for the reaction to proceed in high yields. Additionally, the first examples of domino carbohalogenation reactions have been demonstrated using both aryl iodide and aryl bromide starting materials. Complex products with multiple rings and stereogenic centers are generated in excellent yields with moderate to excellent diastereoselectivities.