Effect of paternal inorganic arsenic exposure on transcriptional profilings of F1-male liver in mouse

Adult male mice (F0) were exposed to 250 ppb inorganic arsenic (iAs) in drinking water before mating with unexposed female mice to generate male F1 offspring (iAsF1-M). Unexposed male mice were bred simultaneously to generate male controls (conF1-M). Both iAsF1-M and conF1-M mice drank normal water without iAs. Adult iAsF1-M and conF1-M mice were harvested to collect liver samples to do RNA-seq. Overall design: Compare the differences in transcriptome profiles between the liver sample from iAsF1-M and conF1-M mice.