CLCA

Primary liver cancer is one of the leading causes of cancer-related death in China. It comprises hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and other rare tumors. HCC accounts for >80% of primary liver cancers and is characterized by high prevalence of multifocality. Multifocal HCC can arise synchronously or metachronously either from intrahepatic metastasis (IM) or multicentric occurrence (MO).

Chinese Liver Cancer Atlas (CLCA) is a multi-omics database focusing on liver cancer in China. Our recent proteogenomic resource of HCC (Genomics, Transcriptomics, Proteomics and Phosphoproteomics) (Gao, et al. Cell. 2019.), IM/MO (Genomics, Transcriptomics, Proteomics) (Dong, et al. J Hepatol. 2020.), and ICC (Genomics, Transcriptomics, Proteomics and Phosphoproteomics) were firstly included in CLCA. CLCA will be integrated with other omics levels and facilitate comprehensive understanding of liver cancer.

原发性肝癌是我国癌症相关死亡的主要诱因之一。其包含肝细胞癌（hepatocellular carcinoma, HCC）、肝内胆管癌（intrahepatic cholangiocarcinoma, ICC）及其他罕见肝癌亚型。肝细胞癌占原发性肝癌总数的80%以上，其显著特征为多灶性高发。多灶性肝细胞癌可通过肝内转移（intrahepatic metastasis, IM）或多中心起源（multicentric occurrence, MO）以同步或异时的方式发生。
中国肝癌图谱（Chinese Liver Cancer Atlas, CLCA）是一款聚焦我国肝癌研究的多组学数据库。本团队前期产出的肝细胞癌蛋白基因组学资源（涵盖基因组学、转录组学、蛋白质组学及磷酸化蛋白质组学数据，Gao 等，《Cell》，2019）、肝内转移/多中心起源相关组学资源（涵盖基因组学、转录组学及蛋白质组学数据，Dong 等，《Journal of Hepatology》，2020）以及肝内胆管癌蛋白基因组学资源（涵盖基因组学、转录组学、蛋白质组学及磷酸化蛋白质组学数据）已率先纳入CLCA。该数据库后续将整合更多组学层级的数据，助力实现对肝癌的全面认知。

搜集汇总

背景与挑战

背景概述

CLCA是中国肝癌多组学数据库，整合了基因组学、转录组学、蛋白质组学和磷酸化蛋白质组学数据，旨在全面研究肝癌。