DNA methylation profiling of phyllodes tumours determines a signature of malignancy and delineates from metaplastic breast carcinoma

Genome wide DNA methylation profiling of phyllodes tumour, fibroadenoma and metaplastic breast cancer samples. The Illumina Infinium Methylation EPIC v1.0 BeadChip Array was used to obtain DNA methylation profiles across approximately 866,000 CpGs from primary tumours. Samples included a range of grades of phyllodes tumours (n=29), fibroadenoma (n=2), and metaplastic breast cancer (n=2). Bisulphite converted DNA from the 33 samples were hybridised to the Illumina Infinium MethylationEPIC v1.0 BeadChip Array