RNA-seq data from control cells and P2RY6-expressing MC38 or CT26 cells. Mus musculus

To delineate the molecular mechanisms by which P2RY6 shapes an immunosuppressive TME and to promote tumor immune evasion, we performed RNA-seq to compare the transcriptomes of P2RY6-expressing MC38 or CT26 cells versus control cells treated the P2RY6 agonist UDP and the master anti-tumor cytokine interferon gamma (IFNγ).