Release of p-PLCG1
收藏reactome.org2025-01-08 收录
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https://reactome.org/PathwayBrowser/#/R-HSA-2424485
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Activated PLC-gamma1 disassociates from LAT. Membrane binding is crucial for PLC-gamma 1 activity. The PH-domain of PLC-gamma 1 binds to phosphatidylinositol 3,4,5-trisphosphate [PdtIns(3,4,5)P3], and is targeted to the membrane (Todderud et al. 1990, Wang & Wang. 2003, Kim et al. 2000). Activated PLCG1 then hydrolyses PIP2 to Inositol 1,4,5-triphosphate (IP3) and DAG
激活的PLC-gamma1与LAT解离。细胞膜结合对于PLC-gamma 1的活性至关重要。PLC-gamma 1的PH结构域与磷脂酰肌醇3,4,5-三磷酸[PdtIns(3,4,5)P3]结合,并被靶向至细胞膜(Todderud等人,1990年,王和王,2003年,金等人,2000年)。随后,激活的PLCG1将PIP2水解为肌醇1,4,5-三磷酸(IP3)和二酰甘油(DAG)。
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