Lem2 is essential for cardiac development by maintaining nuclear integrity. Lem2 is essential for cardiac development by maintaining nuclear integrity

Importantly, mutations in nuclear envelope-encoding genes are the second-highest cause of familial dilated cardiomyopathy. One such nuclear envelope protein that causes cardiomyopathy in humans and affects mouse heart development is Lem2. However, its role in mechanically active tissue such as heart remains poorly understood. Overall design: RNA-Seq on XMLC2V-Cre Lem2 cKO and littermate control whole ventricle at embryonic day 14.5 (E14.5)