Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice

Polychlorinated biphenyls (PCBs) are toxicants present in the environment and are linked to numerous adverse health effects; however, impacts of developmental PCB exposure on lower urinary tract function are understudied. We have previously found developmental exposure (in utero and lactational) to a human-relevant PCB mixture in mice leads to sex- and dose- dependent changes to urinary voiding physiology at 6 weeks of age. This study expands upon previous findings to investigate if developmental PCB-induced urinary voiding phenotypes persist or shift as mice age to 12 weeks of age. Urinary voiding physiology testing through void spot assays, uroflowmetry, and cystometry demonstrated several sex- and dose- dependent effects of PCB exposure at 12 weeks of age. This study demonstrates developmental exposure to PCBs continues to impact lower urinary tract function in adulthood to at least 12 weeks of age both during homeostatic conditions and upon challenge of capsaicin in mice. Better und..., , , # Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice

[https://doi.org/10.5061/dryad.ffbg79d36](https://doi.org/10.5061/dryad.ffbg79d36)

This dataset provides the raw data in excel format collected for all endpoints presented in the above named manuscript for void spot assay, uroflow, cystometry with saline, cystometry with saline versus capsaicin and mouse tissue wet weights of prostate, seminal vesicle, and testes for mice developmentally exposed to PCBs and collected at 12 weeks of age. 

## Description of the data and file structure

Mouse offspring which were developmentally exposed to PCBs underwent voiding physiology testing and assessment of tissue mass. The data for each endpoint examined are in the excel sheet with male and female data labeled, and the title of the endpoint labeled at the top of each data set. Each tab of the excel sheet is an assay and corresponds to ...,