A Convenient Synthesis of C-22 and C-25 Stereoisomers of Cephalostatin North 1 Side Chain from Spirostan Sapogenins
收藏NIAID Data Ecosystem2026-03-06 收录
下载链接：
https://figshare.com/articles/dataset/A_Convenient_Synthesis_of_C-22_and_C-25_Stereoisomers_of_Cephalostatin_North_1_Side_Chain_from_Spirostan_Sapogenins/3742191
下载链接
链接失效反馈官方服务：
资源简介：
A simple transformation of the eight-carbon side chain of a natural spirostan sapogenin into the cephalostatin north 1 spiroketal moiety is
described. This methodology, based on an intramolecular hydrogen abstraction reaction promoted by alkoxy radicals, permits the synthesis
of C-22 and C-25 stereoisomers of the dioxaspiro[4.4]nonane cephalostatin ring system. The acid-catalyzed isomerization of the spirocenter
in the different isomers is studied.
创建时间：
2016-08-20
