Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that
Several1 studies have revealed that the reactive oxygen species (ROS) induced by antibacterial stimulation accelerates the evolution of antibiotic resistance, which uncovered new links between oxygen
To explore the underlying molecular mechanisms behind DNA damage repair, gene expression profiles of shCtrl- and shPTIP (#1 and #2)-transduced HL-60 cells at 0 min and 180 min after IR were examined b
Aminofluorene DNA adduct at the pre-insertion site of a DNA polymerase Descriptor: 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... Authors: Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P
Ultraviolet (UV) light induces the formation of bulky UV photoproducts in the genome that interfere with DNA replication and transcription. It is well-established how human cells repair UV light-induc