Crystal Structure of EGFR-T790M/C797S in Complex with Brigatinib
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Crystal Structure of EGFR-T790M/C797S in Complex with Brigatinib Descriptor: 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine, Epidermal growth factor receptor Authors: Niggenaber, J, Kleinboelting, S, Mueller, M.P, Rauh, D. Deposit date: 2022-05-25 Release date: 2023-05-03 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines. Acs Med.Chem.Lett., 14, 2023
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2022-05-25
