Table_3_Prognosis of resectable colorectal liver metastases after surgery associated with pathological features of primary tumor.docx

BackgroundSurgery is an important means for patients with colorectal liver metastases (CRLM) to improve their long-term survival, and accurate screening of high-risk factors is crucial to guiding postoperative monitoring and treatment. With this in mind, the aim of this study was to investigate the expression levels and prognostic roles of Mismatch Repair (MMR), Ki67, and Lymphovascular invasion(LVI) in the tumor tissues of colorectal of CRLM.Methods85 Patients with CRLM who received surgical treatment for liver metastases after colorectal cancer resection from June, 2017 and Jan, 2020 were included in this study. Independent risk factors affecting the survival of patients with CRLM were investigated using a Cox regression model and the Kaplan-Meier method, and a nomogram for predicting the OS of patients with CRLM was established according to a Cox multivariate regression model. Calibration plots and Kaplan-Meier curves were used to assess the performance of the nomogram.ResultsThe median survival time was 39 months (95% CI: 32.05-45.950), and MMR, Ki67 and LVI were significantly correlated with prognosis. Univariate analysis indicated that larger metastasis size (p=0.028), more than one liver metastases (p=0.001),higher serum CA199 (p

背景：背景手术是结直肠癌肝转移（CRLM）患者提高其长期生存率的重要手段，而精确筛选高危因素对于指导术后监测和治疗至关重要。鉴于此，本研究旨在探讨Mismatch Repair（MMR）、Ki67和淋巴血管侵犯（LVI）在CRLM肿瘤组织中的表达水平及其预后作用。方法：纳入2017年6月至2020年1月期间接受结直肠癌切除术后的肝转移灶手术治疗的CRLM患者85例。采用Cox回归模型和Kaplan-Meier方法研究了影响CRLM患者生存率的独立风险因素，并根据Cox多因素回归模型建立了预测CRLM患者总生存期的 nomogram。通过校准图和Kaplan-Meier曲线评估了nomogram的性能。结果：中位生存时间为39个月（95% CI：32.05-45.950），MMR、Ki67和LVI与预后显著相关。单因素分析显示，转移灶体积较大（p=0.028）、多发性肝转移（p=0.001）以及血清CA199水平升高（p