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Epoxysilane Rearrangement Induced by a Carbanion Generated by Conjugate Addition of Enolates of Chloroacetate and α-Chloroacetamides: Formation of Functionalized Cyclopropane Derivatives

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Epoxysilane_Rearrangement_Induced_by_a_Carbanion_Generated_by_Conjugate_Addition_of_Enolates_of_Chloroacetate_and_Chloroacetamides_Formation_of_Functionalized_Cyclopropane_Derivatives/3225541
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Reaction of an enoate bearing an epoxysilane moiety at the α-position with lithium enolate of 2-chloroacetamide afforded highly functionalized cyclopropane derivatives via a tandem process that involves Michael addition, ring opening of the epoxide, Brook rearrangement, and intramolecular alkylation.
创建时间:
2016-05-05
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