A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy

LIC1(DYNC1LI1,DYN), along its homologue LIC2, constitutes subunits of the multiprotein cytoplasmic dynein complex. Although the dynein complex is known to play a role in membrane trafficking, organelle positioning, and microtubule organization, the specific functions of these individual LICs are rarely investigated.Knockdown or small molecule inhibition of LIC1 in NSCLC cells significantly suppressed cell proliferation and induced autophagic cell death. Overall design: NCI-H1975 and HCC827 non-small cell lung cancer cells mRNA profiles of treatment with 18E(2.5µM,5µM) or siDYN(#1,#2).