Additional file 1 of An engineered genetic circuit for lactose intolerance alleviation

Additional file 1 Table S1 to S9. Detailed data of results. Table S1: Detailed sequences of all the parts of our designed circuits; Table S2: Raw data for the fluorescence measurement of the protein & promoter; Table S3: Raw data for the fluorescence measurement of the protein & protein interaction of CIII & CII; Table S4: Parameters for tri-stable circuit modelling; Table S5: The variation of pH, β-galactosidase activity and l-lactate dehydrogenase activity in in vitro experiment to confirm the functionality of the circuit; Table S6: The variation of pH of the mice colon in the in vivo experiment to confirm the functionality of the circuit; Table S7: The variation of the β-galactosidase of the mice feces in the in vivo experiment to confirm the functionality of the circuit. Table S8: The experiment design and fecal sample collection of the 21-days in vivo experiment to detect the variation of mice gut microbiota; Table S9: The mean abundance of ASVs in the network and their taxonomic annotations.