Mec1 is activated at the onset of normal S phase by low dNTP pools impeding DNA replication
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Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats
The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells respond appropriately to different levels o
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Multimerization of MYC shields stalled replication forks from RNA polymerase [4sU-seq]
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Here we report the first characterization of replication timing and its regulation in the fission yeast Schizosaccharomyces pombe. We used three different synchronization methods: centrifugal elutriat
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The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos,
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Genome-wide chromatin conformation capture (Hi-C) analysis in fission yeast.. Schizosaccharomyces pombe
The dynamic nature of genome organization impacts critical nuclear functions including the regulation of gene expression, replication and DNA damage repair. Despite significant progress, the mechanism
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