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Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in 2mM Mn2+ for 10 min at 4'C

NIAID Data Ecosystem2026-05-01 收录

V(D)J重组

RAG蛋白-DNA发夹复合物

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Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in 2mM Mn2+ for 10 min at 4'C

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创建时间：

2024-03-27

V(D)J重组

淋巴细胞受体基因重组

A central unanswered question concerning the initial phases of V(D)J recombination has been at which step the 12/23 rule applies. This rule, which governs which variable (V), diversity (D), and joinin

PubMed Central70

CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning [dataset 2]

V(D)J重组

染色质可及性调控

RAG endonuclease initiates antibody heavy chain variable region exon assembly from V, D, and J segments within a chromosomal V(D)J recombination center (RC) by cleaving between paired gene segments an

NIAID Data Ecosystem30

Association of terminal deoxynucleotidyl transferase with Ku

V(D)J重组

DNA损伤修复蛋白

Terminal deoxynucleotidyl transferase (TdT) catalyzes the addition of nucleotides at the junctions of rearranging Ig and T cell receptor gene segments, thereby generating antigen receptor diversity. K

PubMed Central1999-11-23 更新20

NUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome

先天性免疫缺陷疾病

V(D)J重组

Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detec

NIAID Data Ecosystem40

J region use by V14: comparison between experimental and simulation data.

V(D)J重组

*Frequencies of rearrangements of V14 genes were calculated from Figure 2 in Aude-Garcia et al.[10], for the combinations with three J panels, corresponding to series of J genes scattered along the J

NIAID Data Ecosystem30

Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in 2mM Mn2+ for 10 min at 4'C

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