Overview of marketed kinase inhibitors, their applications and biochemical characteristics.

1Based on FDA label information.
2based on biochemical data presented in this work and in ref. [11]. Calculation of selectivity entropy as outlined in ref. [33]. Entropy numbers in italic were calculated from single concentration profilings.
3ponatinib was recently withdrawn from US markets, but is still available outside the US.
4temsirolimus and everolimus inhibit mTOR through complex formation with FKBP12, value indicates binding interaction with FKBP12 [55].