Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]. Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]

We report single-cell gene expression profiling of the zebrafish melanoma cell lines ZMEL1-PRO and ZMEL1-INV under multiple in vitro and in vivo (zebrafish transplant) conditions Overall design: Single-cell RNA-seq of ZMEL1-PRO and ZMEL1-INV cells in one of four conditions: 1) in vitro individual culture; 2) in vitro co-culture; 3) in vivo primary tumors; and 4) in vivo metastases