Effects of broad-spectrum antibiotics on graft-versus-host disease

Following allogeneic hematopoietic stem cell transplantation (allo-HSCT) intestinal bacteria modulate both the risk of infections and graft-versus-host disease (GVHD). Neutropenic fever is common and typically treated with a choice of clinically equivalent antibiotics that target obligately anaerobic bacteria (anaerobes) to varying degrees. We evaluated the effects of broad-spectrum antibiotics on graft-versus-host disease in a murine GVHD model.