Determination of vitamin A total body stores and toxicity indicators in children exposed to large scale food fortification and inflammation

To combat vitamin A deficiency, a serious public health
problem in low income settings, vitamin A supplementation and fortification
programs have been implemented as some of the most cost-effective health
interventions. However, recent survey
data indicate that fortification of multiple food vehicles could mean that more
than 20% of young children might have vitamin A intakes above the safe upper
level of intake, if fortification levels are not adjusted to account for the
impact of other programs.

Since the assessment of excessive intake of vitamin A and
associated risk remains problematic, this multi-disciplinary and multi-national
research program assessed whether multiple exposure to vitamin A programs is
associated with intake levels above the safe upper level of intake, excess
hepatic stores and/or biomarkers of vitamin A toxicity.

The collected data of this project will aid in the validation
of the vitamin A tracer dilution technique in individuals with inflammation, to
evaluate the effectiveness and safety of vitamin A interventions across the
full spectrum of vitamin A status, and the establishment of dietary assessment
methods. Furthermore, the collected data
will help evaluate new and sensitive biomarkers of vitamin A toxicity to
develop potential non-invasive serum markers of toxicity in human
populations. The collected data was
collected from 1-5 year old children from Bangladesh, Guatemala and the
Philippines who were selected based on multiple exposure to vitamin A
intervention programs. The data consists
of dietary and biochemical data describing the nutritional status as well as
socioeconomic and demographic status of all participants. Furthermore, a pig model was used to evaluate
traditional and novel biomarkers of hypervitaminosis A.

为应对低收入环境中维生素A缺乏这一严重的公共卫生问题，维生素A的补充和强化计划已被实施，成为最具成本效益的健康干预措施之一。然而，近期调查数据显示，若不调整强化水平以考量其他项目的影响，对多种食物载体进行强化可能导致超过20%的幼儿维生素A摄入量超过安全上限。鉴于对维生素A过量摄入及其相关风险的评估依然存在难题，本多学科、跨国研究项目旨在探究多次暴露于维生素A计划是否与摄入量超过安全上限、肝内储存过剩以及/或维生素A中毒的生物标志物相关。本项目的收集数据将有助于验证维生素A示踪稀释技术在炎症患者中的应用，以评估维生素A干预措施在全谱系维生素A状态中的有效性和安全性，并建立膳食评估方法。此外，收集的数据还将有助于评估新的、敏感的维生素A中毒生物标志物，以开发潜在的非侵入性人体毒性血清标志物。所收集的数据来自孟加拉国、危地马拉和菲律宾1-5岁儿童，这些儿童基于多次暴露于维生素A干预计划而被选中。数据包括描述所有参与者营养状况、社会经济状况和人口统计数据的膳食和生化数据。此外，还使用猪模型来评估传统和新型维生素A中毒生物标志物。