Characterizing Chromosome Instability Reveals Its Association with Lipid-Associated Macrophages and Clonal Evolution of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma

Primary esophageal squamous cell carcinoma tissues, esophageal squamous cell carcinoma tissues metastasized to lymph node, and non-cancerous adjacent esophageal tissues were profiled by whole-genome sequencing to investigate the chromatin instability and clonal evolution of lymph node metastasis in esophageal squamous cell carcinoma.