Deletion of an evolutionary conserved TAD boundary leads to changes in gene expression, histology and function in mouse testis.
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Deletion of non-coding DNA corresponding to a TAD boundary in mouse model leads to changes in gene expression, histology and function in testis. We used CRISPR-Cas9 to delete a TAD boundary in mice. Consequences of the deletion were investigated using RNA-seq, ChIP-seq and Capture HiC on testis from three replicates per genotype.
