Supplementary Figure 2-Deficient mismatch repair is detected in large to giant congenital melanocytic nevus: gaining insight into etiology and identifying potential treatments.

Supplementary Figure 2. MMR protein loss (deficient MMR) in CMN patients. Protein losses of core MMR genes (MSH6, MSH2, PMS2, or MLH1) were identified in partial CMN patients. These patients were diagnosed as dMMR. The absence of nuclear staining of hair follicle cells, sebaceous gland cells, sweat gland cells, nevus cells, and partial epidermal cells was discovered in protein loss patients. Patient 7 has a bolero GCMN with overgrowth lesions. He has over 200 satellite lesions with diverse phenotypes throughout the body. Protein loss of PMS2 was detected. Patient 85 has a face MCMN without a satellite lesion. Protein loss of PMS2 and MLH1 was detected. LGCMN, large to giant congenital melanocytic nevi; MCMN, medium congenital melanocytic nevi; MMR, mismatch repair.