five

Axl targeting in experimental unilateral ureteral obstruction

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE123674
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We investigated if Axl receptor tyrosine kinase was up-regulated in unilateral ureteral obstruction (UUO) and if blocking of Axl by a small molecule called BGB324 (also called Bemcentinib) reduces fibrosis development in the ligated kidney as compared to treatment with its vehicle alone. Two treatment groups of C57Bl/6JOaHSD mice (both groups n=6), which were treated with either BGB324/Bemcentinib or its vehicle (0.5% hydroxylpropyl-methylcellulose in 0.1% Tween 80).
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2019-03-19
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