Purpose: In this study, we show that mutations of the splicing factor SF3B1 in uveal melanoma (UM) generate immunogenic neo-antigens. Overall design: Thawed PBMC from patient UM1 were stained with PE

NIAID Data Ecosystem30

T-cell receptors targetting shared neoantigen KRAS Q61H in NSCLC and other solid cancers

T细胞工程

新抗原识别

Adoptive cell therapy (ACT) with TCR-engineered T-cells represents a promising alternative to TIL- or CAR-T therapies for patients with advanced solid cancers. Currently, selection of therapeutic TCRs

NIAID Data Ecosystem10

Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H

新抗原识别

抗体-抗原复合物

Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H Descriptor: Beta-2-microglobulin, Cellular tumor antigen p53 peptide, Immunoglobulin heavy chain H2, ... Authors: Wright, K.M

Protein Data Bank Japan2024-11-20 更新40

A novel cooperative therapeutic regimen using gene fusion neoantigen-specific TCR-engineered T cells mediated sustained preclinical efficacy in solid tumors independent on inherent mutation profiling. A novel cooperative therapeutic regimen using gene fusion neoantigen-specific TCR-engineered T cells mediated sustained preclinical efficacy in solid tumors independent on inherent mutation profiling

TCR免疫疗法

新抗原识别

Neoantigens derived from non-synonymous somatic mutations, especially gene fusion mutation, are restricted to tumor cells and thus considered ideal targets for T-cell receptor-engineering T-cells (TCR

NIAID Data Ecosystem20

Additional file 1 of TruNeo: an integrated pipeline improves personalized true tumor neoantigen identification

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