Genome-wide maps of TBP-associated factor (TAF, Taf1) in S.cerevisiae

The goals of this study are to compare Next-Generation-Sequecing (NGS)-derived genome-wide occupancy of TAF (Taf1) comparing with other basal initiation components (TBP and TFIIB), histones (H3, H4, Htz1 and H4 acetylation) and histone regulator complexes (Swr1, Bdf1) in S. cerevisiae.本研究旨在对比通过下一代测序（Next-Generation Sequencing，NGS）获得的酿酒酵母（S. cerevisiae）中TAF（Taf1）的全基因组结合占有率，并将其与其他基础转录起始因子（TBP与TFIIB）、组蛋白（H3、H4、Htz1及H4乙酰化修饰）以及组蛋白调控复合物（Swr1、Bdf1）的全基因组结合占有率进行比较。