16S rat metagenome: Impact of whole blood resuscitation

Traumatic injury and the associated hemorrhagic shock and gut hypoperfusion may ignite a cascade of events starting with gut dysbiosis that then predisposes injured patients to inflammatory and infectious complications resulting in worse outcomes. Given the essential role of the gut microbiome in the immune response and maintenance of health, the implications of dysbiosis following traumatic injury and hospitalization on clinical outcomes are profound. If the gut microbiome is unable to maintain resiliency in the context of traumatic injury and critical illness, patients are at an increased risk for development of a pathobiome and subsequent inflammatory- and infection-related complications.