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Ruthenium-Catalyzed Enantioselective Intramolecular Propargylation of Thiophenes with Propargylic Alcohols

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NIAID Data Ecosystem2026-03-06 收录
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Ruthenium-catalyzed enantioselective cyclization of propargylic alcohols bearing a thiophene moiety affords the corresponding propargylated thiophenes in good to high yields with a high enantioselectivity (up to 97% ee). This catalytic reaction is proposed to proceed via chiral ruthenium-allenylidene complexes as key intermediates.

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2009-05-11
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