five

Spike variant predictions

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https://zenodo.org/record/5156954
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Spike variant glycosylation predictions. (spike_mut_idx.v3.xlsx) > Glycoimpact*: likelihood the glycosylation of a proximal site is perturbed  > mannoseDist*: aggregate Fisher log-OR for any high-mannose (>5mannose) structure (taken from IMRs). LIkelihood high-mannose structures, in general, will increase or decrease > IMR - Expected Change: a combination of proximity information with mannoseDist to estimate joint effect > IMR/InSaNNE prediction: predictions of differential glycosylation from IMRs or InSaNNE respectively   *_seq refers to sequence-based predictions, _str refers to structure-based predictions Generating R code is also provided without raw-data ----- Update v4: Mannose/Complex column updated to Mannose/ Complex+hybrid in v5 v5: Mannose+hybrid / Complex column added (one prediction changed). This column is more relevant to the validation observations.
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2021-08-05
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