ERAP1
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资源简介：
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
本基因编码的蛋白质为一种氨基肽酶，该酶参与修剪HLA I类结合前体，以便它们能够在MHC I类分子上展示。编码的蛋白质可作为单体或与ERAP2形成异源二聚体。此外，该蛋白质可能还通过灭活血管紧张素II参与血压调节。针对此基因，已发现三种转录变体，编码两种不同的异构体。[由RefSeq提供，2010年10月]
提供机构：
Rat Genome Database
