Whole transcriptome profiling of placental pathobiology in SARS-CoV-2 pregnancies identifies a preeclampsia-like gene signature

DSP RNA profiling using the whole transcriptome atlas kit was performed on a cohort of placentae from participants who had contracted SARS-CoV-2 in the third trimester compared to uninfected controls. Differential expression was performed on the trophoblast and villous core stroma cells from the anchoring and terminal villi of placentae from the SARS-CoV-2 cohort (n=7) compared to uninfected controls (n=9).